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当前位置:首页 > 产品中心 > ADC 毒素 > Exatecan Mesylate
Exatecan Mesylate

CAS 号: 169869-90-3 (中文同义词:甲磺酸依喜替康)

所有产品仅用于科学研究,不得用于人体或动物实验。

目录号:HD00031

分子式:C25H26FN3O7S

分子量:531.56

纯度:≥99%

长期储存条件:Store in a tight container at 2-8℃.

描述:DNA topoisomerase I inhibitor

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规格 价格 (EXW) 是否有货 数量 加入购物车
10mg ¥1330.00 有货 - 1 +
25mg ¥2800.00 有货 - 1 +
50mg ¥4900.00 有货 - 1 +
100mg ¥8200.00 有货 - 1 +
生物活性
Exatecan mesylate inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA and inhibiting the religation of DNA breaks, thereby inhibiting DNA replication and triggering apoptotic cell death.
产品资料
参考文献

[1] Nakada T, Masuda T, Naito H, Yoshida M, Ashida S, Morita K, Miyazaki H, Kasuya Y, Ogitani Y, Yamaguchi J, Abe Y, Honda T. Novel antibody drug conjugates containing exatecan derivative-based cytotoxic payloads. Bioorg Med Chem Lett. 2016 Mar 15;26(6):1542-5. doi: 10.1016/j.bmcl.2016.02.020. PubMed PMID: 26898815..

[2] Garrison MA, Hammond LA, Geyer CE Jr, Schwartz G, Tolcher AW, Smetzer L, Figueroa JA, Ducharme M, Coyle J, Takimoto CH, De Jager RL, Rowinsky EK. A Phase I and pharmocokinetic study of exatecan mesylate administered as a protracted 21-day infusion in patients with advanced solid malignancies. Clin Cancer Res. 2003 Jul;9(7):2527-37. PubMed PMID: 12855627..

[3] Braybrooke JP, Ranson M, Manegold C, Mattson K, Thatcher N, Cheverton P, Sekiguchi M, Suzuki M, Oyama R, Talbot DC. Phase II study of exatecan mesylate (DX-8951f) as first line therapy for advanced non-small cell lung cancer. Lung Cancer. 2003 Aug;41(2):215-9. PubMed PMID: 12871785

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