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Ansamitocin P-0

CAS 号: 57103-68-1 (中文同义词:安沙菌素P-0)

所有产品仅用于科学研究,不得用于人体或动物实验。

目录号:HD00034

分子式:C28H37ClN2O8

分子量:565.05

纯度:≥98%

长期储存条件:Store in a tight container at 2-8℃.

描述:Microtubule inhibitor

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10mg ¥1050.00 有货 - 1 +
25mg ¥1500.00 有货 - 1 +
50mg ¥2100.00 有货 - 1 +
100mg ¥2850.00 有货 - 1 +
1g 询价 有货 - 1 +
生物活性

It was shown to inhibit microtubule assembly and induces microtubule disassembly in vitro. It exhibits antitumor activity. Maytansinol inhibits microtubule assembly. Maytansinol disrupts the mitotic spindle and prevents mitotic exit in Drosophila.

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参考文献

[1] Feng L, Yao HP, Zhou YQ, Zhou J, Zhang R, Wang MH. Biological evaluation of antibody-maytansinoid conjugates as a strategy of RON targeted drug delivery for treatment of non-small cell lung cancer. J Exp Clin Cancer Res. 2016 Apr 22;35:70. doi: 10.1186/s13046-016-0347-6. Erratum in: J Exp Clin Cancer Res. 2016;35(1):95. PubMed PMID: 27102688; PubMed Central PMCID: PMC4840490.

[2] Edwards A,et al. Combinatorial effect of maytansinol and radiation in Drosophila and human cancer cells. Dis Model Mech. 2011 Jul;4(4):496-503. PMID:21504911.

[3] Edwards A, Gladstone M, Yoon P, Raben D, Frederick B, Su TT. Combinatorial effect of maytansinol and radiation in Drosophila and human cancer cells. Dis Model Mech. 2011 Jul;4(4):496-503. doi: 10.1242/dmm.006486. Epub 2011 Apr 18. PubMed PMID: 21504911; PubMed Central PMCID: PMC3124055.

[4] Sawada T, Kato Y, Kobayashi H, Hashimoto Y, Watanabe T, Sugiyama Y, Iwasaki S. A fluorescent probe and a photoaffinity labeling reagent to study the binding site of maytansine and rhizoxin on tubulin. Bioconjug Chem. 1993 Jul-Aug;4(4):284-9. PubMed PMID: 8218485.

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