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DM1

CAS 号: 139504-50-0 (中文同义词:美登素DM1)

所有产品仅用于科学研究,不得用于人体或动物实验。

目录号:HD00037

分子式:C35H48ClN3O10S

分子量:738.29

纯度:≥98%

长期储存条件:Store in a tight container at -20℃.

描述:Tubulin depolymerization

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规格 价格 (EXW) 是否有货 数量 加入购物车
10mg ¥920.00 有货 - 1 +
25mg ¥1450.00 有货 - 1 +
50mg ¥2150.00 有货 - 1 +
100mg ¥2860.00 有货 - 1 +
1g 询价 有货 - 1 +
生物活性

Mertansine is a tubulin inhibitor, meaning that it inhibits the assembly of microtubules by binding to tubulin (at the rhizoxin binding site). Mertansine (DM1) is an antibody-conjugatable maytansinoid that is developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery. Mertansine can be attached to a monoclonal antibody with a linker to create an antibody-drug conjugate (ADC).

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参考文献

[1] Koniev O, Kolodych S, Baatarkhuu Z, Stojko J, Eberova J, Bonnefoy JY, Cianférani S, Van Dorsselaer A, Wagner A. MAPN: First-in-Class Reagent for Kinetically Resolved Thiol-to-Thiol Conjugation. Bioconjug Chem. 2015 Sep 3. [Epub ahead of print] PubMed PMID: 26335849.

[2] Manu Lopus et al. Maytansine and Cellular Metabolites of Antibody-Maytansinoid Conjugates Strongly Suppress Microtubule Dynamics by Binding to Microtubules.

[3] Van den Mooter T, Teuwen LA, Rutten A, Dirix L. Trastuzumab emtansine in advanced human epidermal growth factor receptor 2-positive breast cancer. Expert Opin Biol Ther. 2015 May;15(5):749-60. doi: 10.1517/14712598.2015.1036026. PubMed PMID: 25865453.

[4] Lopus M. Antibody-DM1 conjugates as cancer therapeutics. Cancer Lett. 2011 Aug 28;307(2):113-8.

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