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DM4

CAS 号: 796073-69-3 (中文同义词:美登素 DM4)

所有产品仅用于科学研究,不得用于人体或动物实验。

目录号:HD00038

分子式:C38H54ClN3O10S

分子量:780.37

纯度:≥98%

长期储存条件:Store in a tight container at -20℃.

描述:Tubulin depolymerization

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规格 价格 (EXW) 是否有货 数量 加入购物车
10mg ¥1500.00 有货 - 1 +
25mg ¥2650.00 有货 - 1 +
50mg ¥4500.00 有货 - 1 +
100mg ¥7150.00 有货 - 1 +
1g 询价 有货 - 1 +
生物活性

DM4 is an antitubulin agent that inhibit cell division. DM4 can be used in the preparation of antibody drug conjugate. It is a structural analogue of maytansine, is a new thiol-containing and potent maytansinoid. DM4 is a cytotoxic maytansinoid drug. It is synthesized in order to link maytansinoids to antibodies via disulfide bonds. Maytansinoids inhibit tubulin polymerization and microtubule assembly and enhance microtubule destabilization, so there is potent suppression of microtubule dynamics resulting in a mitotic block and subsequent apoptotic cell death.

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参考文献
[1] Tang R, et al. P-gp activity is a critical resistance factor against AVE9633 and DM4 cytotoxicity in leukaemia cell lines, but not a major mechanism of chemoresistance in cells from acute myeloid leukaemia patients. BMC Cancer. 2009 Jun 23;9:199.

[2] Coiffier B, Thieblemont C, de Guibert S, Dupuis J, Ribrag V, Bouabdallah R, Morschhauser F, Navarro R, Le Gouill S, Haioun C, Houot R, Casasnovas O, Holte H, Lamy T, Broussais F, Payrard S, Hatteville L, Tilly H. A phase II, single-arm, multicentre study of coltuximab ravtansine (SAR3419) and rituximab in patients with relapsed or refractory diffuse large B-cell lymphoma. Br J Haematol. 2016 Jun;173(5):722-30. doi: 10.1111/bjh.13992. Epub 2016 Mar 24. PubMed PMID: 27010483.

[3] Hassan R, Thomas A, Alewine C, Le DT, Jaffee EM, Pastan I. Mesothelin Immunotherapy for Cancer: Ready for Prime Time? J Clin Oncol. 2016 Dec;34(34):4171-4179. Epub 2016 Oct 31. PubMed PMID: 27863199.

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