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MMAF

CAS 号: 745017-94-1 (中文同义词:一甲基澳瑞他汀 F)

所有产品仅用于科学研究,不得用于人体或动物实验。

目录号:HD00039

分子式:C39H65N5O8

分子量:731.96

纯度:≥95%

长期储存条件:Store in a tight container at 2-8℃.

描述:Tubulin polymerase inhibitor

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规格 价格 (EXW) 是否有货 数量 加入购物车
10mg ¥450.00 有货 - 1 +
25mg ¥950.00 有货 - 1 +
50mg ¥1350.00 有货 - 1 +
100mg ¥2300.00 有货 - 1 +
1g ¥6000.00 有货 - 1 +
生物活性

MMAF (Monomethylauristatin F) is an antineoplastic agent and a tubulin polymerization inhibitor and is used as a antitumor agent. MMAF (Monomethylauristatin F) is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as vorsetuzumab mafodotin and SGN-CD19A.

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参考文献

[1] Yao X, Jiang J, Wang X, Huang C, Li D, Xie K, Xu Q, Li H, Li Z, Lou L, Fang J. A novel humanized anti-HER2 antibody conjugated with MMAE exerts potent anti-tumor activity. Breast Cancer Res Treat. 2015 Aug;153(1):123-33. doi: 10.1007/s10549-015-3503-3. Epub 2015 Aug 8. PubMed PMID: 26253944.

[2] Leal M, Wentland J, Han X, Zhang Y, Rago B, Duriga N, Spriggs F, Kadar E, Song W, McNally J, Shakey Q, Lorello L, Lucas J, Sapra P. Preclinical Development of an anti-5T4 Antibody-Drug Conjugate: Pharmacokinetics in Mice, Rats, and NHP and Tumor/Tissue Distribution in Mice. Bioconjug Chem. 2015 Nov 18;26(11):2223-32. doi: 10.1021/acs.bioconjchem.5b00205. Epub 2015 Jul 16. PubMed PMID: 26180901.

[3] Kim EG, et al. Strategies and Advancement in Antibody-Drug Conjugate Optimization for Targeted CancerTherapeutics.

[4] Doronina SO, et al. Enhanced activity of monomethylauristatin F through monoclonal antibody delivery: effects of linker technology on efficacy and toxicity. Bioconjug Chem. 2006 Jan-Feb;17(1):114-24.

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