CAS 号： 163768-50-1 （中文同义词：澳瑞他汀F）
所有产品仅用于科学研究，不得用于人体或动物实验。
目录号：HD00044
分子式：C40H67N5O8
分子量：746.00
纯度：≥95%
长期储存条件：Store in a tight container at 2-8℃.
描述：Microtubule inhibitor
| 规格 | 价格 (EXW) | 是否有货 | 数量 | 加入购物车 |
|---|---|---|---|---|
| 10mg | ￥450.00 | 有货 | - 1 + | |
| 25mg | ￥950.00 | 有货 | - 1 + | |
| 50mg | ￥1350.00 | 有货 | - 1 + | |
| 100mg | ￥2300.00 | 有货 | - 1 + | |
| 1g | ￥6000.00 | 有货 | - 1 + |
Auristatin F is a synthetic analog of dolastatin 10. Auristatin F is a highly potent antimitotic agent. Auristatin F inhibits tubulin polymerization. Auristatin F-antibody cunjugates have proven to be successful anticancer agents.
[1] Roy S, et al. SMI-Ribosome inactivating protein conjugates selectively inhibit tumor cell growth. Chem Commun (Camb). 2017 Apr 11;53(30):4234-4237.
[2] Powell Gray B, Kelly L, Ahrens DP, Barry AP, Kratschmer C, Levy M, Sullenger BA. Tunable cytotoxic aptamer-drug conjugates for the treatment of prostate cancer. Proc Natl Acad Sci U S A. 2018 May 1;115(18):4761-4766. doi: 10.1073/pnas.1717705115. Epub 2018 Apr 16. PubMed PMID: 29666232; PubMed Central PMCID: PMC5939073.
[3] Johansson MP, Maaheimo H, Ekholm FS. New insight on the structural features of the cytotoxic auristatins MMAE and MMAF revealed by combined NMR spectroscopy and quantum chemical modelling. Sci Rep. 2017 Nov 21;7(1):15920. doi: 10.1038/s41598-017-15674-1. PubMed PMID: 29162861; PubMed Central PMCID: PMC5698355.
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