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Plitidepsin

CAS 号： 137219-37-5 （中文同义词：普利地星）

所有产品仅用于科学研究，不得用于人体或动物实验。

目录号：HD00053

分子式：C₅₇H₈₇N₇O₁₅

分子量：1110.34

纯度：≥98%

长期储存条件：Store in a tight container at 2-8℃.

描述：A Repurposed Drug for the Treatment of COVID-19；Antitumor

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规格	价格 (EXW)	是否有货	数量
1mg	￥5750.00	有货	- 1 +
10mg	￥11380.00	有货	- 1 +
50mg	￥43050.00	有货	- 1 +
100mg	询价	有货	- 1 +

生物活性

Plitidepsin is a cyclic depsipeptide isolated from the marine tunicate Aplidium albicans. Plitidepsin displays a broad spectrum of antitumor activities, inducing apoptosis by triggering mitochondrial cytochrome c release, initiating the Fas/DC95, JNK pathway and activating caspase 3 activation. This agent also inhibits elongation factor 1-a, thereby interfering with protein synthesis, and induces G1 arrest and G2 blockade, thereby inhibiting tumor cell growth.Plitidepsin, an inhibitor of SARS-Cov-2 in vitro, is safe and positively influences the outcome of patients hospitalized with COVID-19.

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参考文献

[1] Pardanani A, Tefferi A, Guglielmelli P, Bogani C, Bartalucci N, Rodríguez J, Extremera S, Pérez I, Alfaro V, Vannucchi AM. Evaluation of plitidepsin in patients with primary myelofibrosis and post polycythemia vera/essential thrombocythemia myelofibrosis: results of preclinical studies and a phase II clinical trial. Blood Cancer J. 2015 Mar 13;5:e286.

[2] Lollo G, Hervella P, Calvo P, Avilés P, Guillén MJ, Garcia-Fuentes M, Alonso MJ, Torres D. Enhanced in vivo therapeutic efficacy of plitidepsin-loaded nanocapsules decorated with a new poly-aminoacid-PEG derivative. Int J Pharm. 2015 Apr 10;483(1-2):212-9.

[3] Plitidepsin has a positive therapeutic index in adult patients with COVID-19 requiring hospitalization. José F. Varona,et al. doi: https://doi.org/10.1101/2021.05.25.21257505.

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Plitidepsin

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