It is produced by the strain of Streptomyces sp. DT136. Cochleamycin A showed strong inhibitory activity against tumor cells, with IC50 (μg/mL) of P388, HL60, K562, COL0205 and HT29 cells of 1.6, 14.0, 6.2, 16.5 and 19.1, respectively. It also has anti-gram-positive bacteria activity.