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Chromomycin A3

CAS 号: 7059-24-7 (中文同义词:色霉素 A3)

所有产品仅用于科学研究,不得用于人体或动物实验。

目录号:HD00022

分子式:C57H82O26

分子量:1183.25

纯度:≥98%

长期储存条件:Store in a tight container at -20℃.

描述:a glycosidic antineoplastic antibiotic.

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生物活性
Chromomycin A3 belong to the class of antitumor compounds called aureolic acids, it inhibits growth and multiplication of several tumor cell lines and also act on gram-positive bacteria. It binds via minor groove of DNA with GC-base specificity in presence of bivalent metal ions like Mg2+ and thereby inhibits replication and transcription.
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参考文献

[1] Lahiri S, Takao T, Devi P G, et al. Association of aureolic acid antibiotic, chromomycin A3 with Cu 2+ and its negative effect upon DNA binding property of the antibiotic[J]. Biometals, 2012, 25(2): 435-450.

[2] Menendez N, Nur-e-Alam M, Brana A F, et al. Biosynthesis of the antitumor chromomycin A3 in Streptomyces griseus: analysis of the gene cluster and rational design of novel chromomycin analogs[J]. Chemistry & biology, 2004, 11(1): 21-32. 

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