CAS 号： 104987-11-3 （中文同义词：他克莫司）
所有产品仅用于科学研究，不得用于人体或动物实验。
目录号：HD00122
分子式：C44H69NO12
分子量：804.02
纯度：≥98%
长期储存条件：Store in a tight container at -20℃
描述：Potent immunity inhibitor.
Tacrolimus (FK506), a macrocyclic lactone, a calcineurin inhibitor (CNI), is the first-line immunosuppressant , which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties.
[1] Thomson AW, et al. Mode of action of Tacrolimus (FK506): molecular and cellular mechanisms. Ther Drug Monit. 1995 Dec;17(6):584-91.
[2] Vogel KR, et al. mTOR inhibitors rescue premature lethality and attenuate dysregulation of GABAergic/glutamatergic transcription in murine succinate semialdehyde dehydrogenase deficiency (SSADHD), a disorder of GABA metabolism. J Inherit Metab Dis. 2016 Nov;39(6):877-886.
[3] Zhu H, et al. Tacrolimus promotes hepatocellular carcinoma and enhances CXCR4/SDF 1α expression in vivo. Mol Med Rep. 2014 Aug;10(2):585-92.
[4] Okada Y, et al. Tacrolimus ameliorates dextran sulfate sodium-induced colitis in mice: implication of interleukin-1β suppression. Biol Pharm Bull. 2011;34(12):1823-7.
[5] Meng Yu,et al.Pharmacokinetics, Pharmacodynamics and Pharmacogenetics of Tacrolimus in Kidney Transplantation.Curr Drug Metab. 2018;19(6):513-522.
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