Pseudouridimycin (PUM) is a novel pseudouridine-contg. peptidyl-nucleoside antibiotic that inhibits bacterial RNA polymerase (RNAP) through a binding site and mechanism different from those of clin. approved RNAP inhibitors of the rifamycin and lipiarmycin (fidaxomicin) classes. PUM was discovered by screening microbial fermn. exts. for RNAP inhibitors.

[1]Sonia I Maffioli 1, Margherita Sosio 1, Richard H Ebright 2, Stefano Donadio 3, Discovery, properties, and biosynthesis of pseudouridimycin, an antibacterial nucleoside-analog inhibitor of bacterial RNA polymerase, J Ind Microbiol Biotechnol. 2019 Mar;46(3-4):335-343.