CAS 号： 137071-32-0 （中文同义词：吡美莫司）
所有产品仅用于科学研究，不得用于人体或动物实验。
目录号：HD00140
分子式：C43H68ClNO11
分子量：810.45
纯度：≥99%
长期储存条件：Store in a tight container between 2-8℃.
描述：Inhibitor of inflammatory cytokines secretion
Pimecrolimus is an immunomodulating agent of the calcineurin inhibitor class used in the treatment of atopic dermatitis. Pimecrolimus is an ascomycin macrolactam derivative. Pimecrolimus binds to the receptor macrophilin-12 (FKBP-12) forming a complex that blocks the calcium-dependent signal transduction cascade mediated by calcineurin.
[1] Grassberger M, Baumruker T, Enz A, Hiestand P, Hultsch T, Kalthoff F, Schuler W, Schulz M, Werner FJ, Winiski A, Wolff B, Zenke G: A novel anti-inflammatory drug, SDZ ASM 981, for the treatment of skin diseases: in vitro pharmacology. Br J Dermatol. 1999 Aug;141(2):264-73.
[2] Gupta, A.K. and M. Chow, Pimecrolimus: a review. J Eur Acad Dermatol Venereol, 2003. 17(5): p. 493-503.
[3] Boone B, Ongenae K, Van Geel N, Vernijns S, De Keyser S, Naeyaert JM (2007). "Topical pimecrolimus in the treatment of vitiligo". Eur J Dermatol. 17 (1): 55–61. doi:10.1684/ejd.2007.0093 (inactive 31 May 2021). PMID 17324829.
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