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Illudin S

CAS 号: 1149-99-1 (中文同义词:隐陡头菌素S)

所有产品仅用于科学研究,不得用于人体或动物实验。

目录号:HD00064

分子式:C15H20O4

分子量:264.32

纯度:≥95%

长期储存条件:Store in a tight container at -20℃.

描述:DNA Alkylator

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10mg ¥9880.00 有货 - 1 +
25mg 询价 有货 - 1 +
生物活性

Illudin S is a cytotoxic Illudin, a genetically toxic natural sesquiterpene with strong anti-tumor and anti-viral activities. Illudin S blocks the G1-S phase interface of the human leukemia cell cycle.

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参考文献

[1] Glatt H, Pietsch KE, Sturla SJ, Meinl W. Sulfotransferase-independent genotoxicity of illudin S and its acylfulvene derivatives in bacterial and mammalian cells. Arch Toxicol. 2014 Jan;88(1):161-9.

[2] Tanaka K, Inoue T, Kadota S, Kikuchi T. Metabolism by rat liver cytosol of illudin S, a toxic substance of Lampteromyces japonicus. II. Characterization of illudin S-metabolizing enzyme. Xenobiotica. 1992 Jan;22(1):33-9.

[3] Pietsch KE, van Midwoud PM, Villalta PW, Sturla SJ. Quantification of acylfulvene- and illudin S-DNA adducts in cells with variable bioactivation capacities. Chem Res Toxicol. 2013 Jan 18;26(1):146-55.

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