CAS 号： 12684-33-2 （中文同义词：西伯利亚霉素）
所有产品仅用于科学研究，不得用于人体或动物实验。
目录号：HD00007
分子式：C24H33N3O7
分子量：475.53
纯度：≥95%
长期储存条件：Store in a tight container at -20°C.
描述：A naturally produced glycosylated pyrrolobenzodiazepines
Sibiromycin, a naturally produced glycosylated pyrrolobenzodiazepines (PBDs), displays the highest affinity for DNA and the most potent antitumor properties. Sibiromycin is also a potent antitumor antibiotic that binds covalently to DNA in the minor groove at the NH2 of guanine.
[1] Wei Li, Ankush Khullar, Shenchieh Chou, Ashley Sacramo, Barbara Gerratana, Biosynthesis of sibiromycin, a potent antitumor antibiotic, Appl Environ Microbiol. 2009 May;75(9):2869-78. doi: 10.1128/AEM.02326-08. Epub 2009 Mar 6.
[2] Gerratana B. Biosynthesis, synthesis, and biological activities of pyrrolobenzodiazepines. Med Res Rev. 2012;32(2):254-293.
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