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Staurosporine

CAS 号: 62996-74-1 (中文同义词:星孢菌素)

所有产品仅用于科学研究,不得用于人体或动物实验。

目录号:HD00012

分子式:C28H26N4O3

分子量:466.53

纯度:≥95%

长期储存条件:Store in a tight container between 2-8℃.

描述:Protein kinase inhibitor

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25mg ¥1870.00 有货 - 1 +
100mg ¥5970.00 有货 - 1 +
生物活性

Staurosporine, also known as antibiotic AM-2282 or STS, is a potent, non-selective inhibitor of protein kinases, including protein kinase C with promising anti-cancer activity. Staurosporine is a natural product originally isolated in 1977 from the bacterium Streptomyces staurosporeus. Staurosporine was discovered to have biological activities ranging from anti-fungal to anti-hypertensive. The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity.

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参考文献

[1] Nabeshima T, et al. Staurosporine facilitates recovery from the basal forebrain-lesion-induced impairment of learning and deficit of cholinergic neuron in rats. J Pharmacol Exp Ther. 1991 May;257(2):562-6.

[2] Chae HJ, et al. Molecular mechanism of staurosporine-induced apoptosis in osteoblasts. Pharmacol Res. 2000 Oct;42(4):373-81.

[3] Meggio F, et al. Different susceptibility of protein kinases to staurosporine inhibition. Kinetic studies and molecular bases for the resistance of protein kinase CK2. Eur J Biochem. 1995 Nov 15;234(1):317-22.

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