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N-Acetyl-Calicheamicin

CAS 号: 108212-76-6 (中文同义词:N-乙酰-凯立霉素)

所有产品仅用于科学研究,不得用于人体或动物实验。

目录号:HD00043

分子式:C57H76IN3O22S4

分子量:1410.39

纯度:≥90%

长期储存条件:Store in a tight container at -20℃.

描述:DNA synthesis inhibitor

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生物活性

N-Acetyl calicheamicin is a derivative of calicheamicin, and is a potent enediyne antitumor antibiotic. Calicheamicins target DNA and cause strand scission. Calicheamicins bind with DNA in the minor groove, wherein they then undergo a reaction analogous to the Bergman cyclization to generate a diradical species. This diradical, 1,4-didehydrobenzene, then abstracts hydrogen atoms from the deoxyribose (sugar) backbone of DNA, which ultimately leads to strand scission. The specificity of binding of calicheamicin to the minor groove of DNA was demonstrated by Crothers et al. (1999) to be due to the aryltetrasaccharide group of the molecule.

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参考文献

[1] Stasi R, et al. Gemtuzumab ozogamicin in the treatment of acute myeloid leukemia. Cancer Treat Rev. 2008 Feb;34(1):49-60.

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