CAS 号： 1599440-33-1 （中文同义词：依喜替康衍生物）
所有产品仅用于科学研究，不得用于人体或动物实验。
目录号：HD00056
分子式：C26H24FN3O6
分子量：493.49
纯度：≥95%
长期储存条件：Store in a tight container at -20°C under nitrogen.
描述：DNA topoisomerase I Inhibitor
DXD (Exatecan derivative for ADC) is a potent DNA topoisomerase I inhibitor, with an IC50 of 0.31 μM, used as a conjugated drug of HER2-targeting ADC (DS-8201a).
[1] Ogitani Y, et al. DS-8201a, A Novel HER2-Targeting ADC with a Novel DNA Topoisomerase I Inhibitor, Demonstrates a Promising Antitumor Efficacy with Differentiation from T-DM1. Clin Cancer Res. 2016 Oct 15;22(20):5097-5108.
[2] Ogitani Y, Abe Y, Iguchi T, Yamaguchi J, Terauchi T, Kitamura M, Goto K, Goto M, Oitate M, Yukinaga H, Yabe Y, Nakada T, Masuda T, Morita K, Agatsuma T. Wide application of a novel topoisomerase I inhibitor-based drug conjugation technology. Bioorg Med Chem Lett. 2016 Oct 15;26(20):5069-5072. doi: 10.1016/j.bmcl.2016.08.082. Epub 2016 Aug 27. PubMed PMID: 27599744.
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