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Porfiromycin

CAS 号: 801-52-5 (中文同义词:泊非霉素)

所有产品仅用于科学研究,不得用于人体或动物实验。

目录号:HD00060

分子式:C16H20N4O5

分子量:348.35

纯度:≥95%

长期储存条件:Store in a tight container at -20°C.

描述:DNA synthesis inhibitor

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Porfiromycin is a n N-methyl derivative of the antineoplastic antibiotic mitomycin C isolated from the bacterium Streptomyces ardus and other Streptomyces bacterial species. Bioreduced porfiromycin generates oxygen radicals and alkylates DNA, producing interstrand cross-links and single-strand breaks, thereby inhibiting DNA synthesis. Porfiromycin is preferentially toxic to hypoxic cells. It belongs to the family of drugs called anticancer antibiotics.

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参考文献

[1] Rockwell S, Hughes CS. Effects of mitomycin C and porfiromycin on exponentially growing and plateau phase cultures. Cell Prolif. 1994 Mar;27(3):153-63. PubMed PMID: 10465006.

[2] Lee SH, Kohn H. Cyclic disulfide C8 iminoporfiromycin: nucleophilic activation of a porfiromycin. J Am Chem Soc. 2004 Apr 7;126(13):4281-92.

[3] Lang W, Mao J, Doyle TW, Almassian B. Isolation and identification of urinary metabolites of porfiromycin in dogs and humans. Drug Metab Dispos. 2000 Aug;28(8):899-904. 

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