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SMCC

CAS 号: 64987-85-5 (中文同义词:4-(N-马来酰亚胺基甲基)环己烷-1-羧酸琥珀酰亚胺酯)

所有产品仅用于科学研究,不得用于人体或动物实验。

目录号:HD00085

分子式:C16H18N2O6

分子量:334.32

纯度:≥95%

长期储存条件:Store in a tight container at -20°C.

描述:Protein crosslinker

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SMCC, also known as succinimidyl-4-[N-maleimidomethyl]cyclohexane-1-carboxylate, is a heterobifunctional protein crosslinker. SMCC is an amine-to-sulfhydryl crosslinker that contains NHS-ester and maleimide reactive groups at opposite ends of a medium-length cyclohexane-stabilized spacer arm (8.3 angstroms). SMCC conjugation occurs via a maleimide group that is sulfhydryl (thiol; -SH) reactive and a NHS ester group that is amine reactive and forms stable, covalent protein crosslinks.

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参考文献

[1] Guo Y, et al. Potent antigen-specific immune response induced by infusion of spleen cells coupled with succinimidyl-4-(N-maleimidomethyl cyclohexane)-1-carboxylate (SMCC) conjugated antigens. Int Immunopharmacol. 2016 Feb;31:158-68.

[2] Li C, Lin Q, Wang J, Shen L, Ma G, Su Z, Hu T. Preparation, structural analysis and bioactivity of ribonuclease A-albumin conjugate: tetra-conjugation or PEG as the linker. J Biotechnol. 2012 Dec 31;162(2-3):283-8. doi: 10.1016/j.jbiotec.2012.09.008. Epub 2012 Sep 20. PubMed PMID: 23000658.

[3] Christie RJ, Anderson DJ, Grainger DW. Comparison of hydrazone heterobifunctional cross-linking agents for reversible conjugation of thiol-containing chemistry. Bioconjug Chem. 2010 Oct 20;21(10):1779-87. doi: 10.1021/bc100049c. PubMed PMID: 20695431; PubMed Central PMCID: PMC2958219.

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