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MC-Val-Cit-PAB

CAS 号: 159857-80-4

所有产品仅用于科学研究,不得用于人体或动物实验。

目录号:HD00087

分子式:C28H40N6O7

分子量:572.65

纯度:≥95%

长期储存条件:Store in a tight container at 2-8 ℃.

描述:Cleavable ADC linker

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Mc-Val-Cit-PAB is a peptide linker molecule used in the synthesis of antibody-drug conjugates (ADCs). It contains a maleimidocaproyl (Mc) group that can be conjugated to an antibody and a p-aminobenzyl (PAB) spacer that allows the peptide to be linked to active compounds, such as anticancer agents. Mc-Val-Cit-PAB is cleaved in vivo by cathepsin B, a protease highly expressed in cancer cells, which confers specificity of the ADC to cancer cells.

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[1] Anti-cd70 antibody-drug conjugates and their use for the treatment of cancer and immune disorders.

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