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Acarbose

CAS 号: 56180-94-0 (中文同义词:阿卡波糖)

所有产品仅用于科学研究,不得用于人体或动物实验。

目录号:HD00364

分子式:C25H43NO18

分子量:645.6

纯度:≥95%

长期储存条件:Store in a tight container at -20℃.

描述:An orally active alpha-glucosidase inhibitor

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Acarbose is an α-glucosidase inhibitor that improves glycemic control by decreasing the intestinal absorption of glucose, thereby decreasing the elevation of postprandial blood glucose. Acarbose can potentiate the hypoglycemic effects of sulfonylureas or insulin.

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参考文献

[1] Chan KC, et al. Pleiotropic effects of acarbose on atherosclerosis development in rabbits are mediated via upregulating AMPK signals. Sci Rep. 2016 Dec 7;6:3864.

[2] Yee HS, et al. A review of the safety and efficacy of acarbose in diabetes mellitus. Pharmacotherapy. 1996;16(5):792-805.

[3] Hanefeld M, et al. Acarbose: oral anti-diabetes drug with additional cardiovascular benefits [published correction appears in Expert Rev Cardiovasc Ther. 2009 Mar;7(3):330]. Expert Rev Cardiovasc Ther. 2008;6(2):153-163.

[4] Oki T, et al. Evaluation of alpha-glucosidase inhibition by using an immobilized assay system. Biol Pharm Bull. 2000;23(9):1084-1087.

[5] Zhang Q, et al. Acarbose Reduces Blood Glucose by Activating miR-10a-5p and miR-664 in Diabetic Rats. PLoS One. 2013 Nov 18;8(11):e79697.

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