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Pioglitazone hydrochloride

CAS 号: 112529-15-4 (中文同义词:盐酸吡格列酮)

所有产品仅用于科学研究,不得用于人体或动物实验。

目录号:HD00416

分子式:C19H21ClN2O3S

分子量:392.9

纯度:≥95%

长期储存条件:Store in a tight container at -20℃.

描述:Thiazolidinedione antidiabetic drugs

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生物活性
Pioglitazone is an agonist of the peroxisome proliferator-activated receptor γ.
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参考文献

[1] Kuwabara K, et al. A novel selective peroxisome proliferator-activated receptor alpha agonist, 2-methyl-c-5-[4-[5-methyl-2-(4-methylphenyl)-4-oxazolyl]butyl]-1,3-dioxane-r-2-carboxylic acid (NS-220), potently decreases plasma triglyceride and glucose leve

[2] Puddu A, et al. Pioglitazone attenuates the detrimental effects of advanced glycation end-products in the pancreatic beta cell line HIT-T15. Regul Pept. 2012 Aug 20;177(1-3):79-84.

[3] Kubota N, et al. Pioglitazone ameliorates insulin resistance and diabetes by both adiponectin-dependent and -independent pathways. J Biol Chem. 2006 Mar 31;281(13):8748-55.

[4] Elrashidy RA, et al. Pioglitazone attenuates cardiac fibrosis and hypertrophy in a rat model of diabetic nephropathy. J Cardiovasc Pharmacol Ther. 2012 Sep;17(3):324-33.

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