CAS 号： 11006-33-0 （中文同义词：腐草霉素）
所有产品仅用于科学研究，不得用于人体或动物实验。
目录号：HD00068
分子式：C51H75N17O21S2
分子量：1326.4
纯度：≥95%
长期储存条件：Store in a tight container at -20℃.
描述：Glycopeptide antibiotic
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Phleomycin is an anticancer glycopeptide antibiotic found in Streptomyces verticillus, which cause DNA cleavage. Phleomycin binds and intercalates DNA to damage the integrity of the double helix.
[1] Moore CW. Control of in vivo (cellular) phleomycin sensitivity by nuclear genotype, growth phase, and metal ions. Cancer Res. 1982 Mar;42(3):929-33.
[2] van Peer AF, de Bekker C, Vinck A, Wösten HA, Lugones LG. Phleomycin increases transformation efficiency and promotes single integrations in Schizophyllum commune. Appl Environ Microbiol. 2009 Mar;75(5):1243-7.
[3] Stokowa-Sołtys K, Dzyhovskyi V, Wieczorek R, Jeżowska-Bojczuk M. Phleomycin complex - Coordination mode and in vitro cleavage of DNA. J Inorg Biochem. 2019 Jun;195:71-82.
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