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Nicotinamide

CAS 号: 98-92-0 (中文同义词:烟酰胺)

所有产品仅用于科学研究,不得用于人体或动物实验。

目录号:HD00255

分子式:C6H6N2O

分子量:122.12

纯度:≥95%

长期储存条件:Store in a tight container between 2-8℃, protect from light.

描述:Form of vitamin B3, inhibitor of SIRT1.

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Nicotinamide is a form of vitamin B3 and it is also an NAD+ precursor and inhibitor of SIRT1.

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参考文献

[1] Bhansali SG, et al. Nicotinamide prevents apoptosis in human cortical neuronal cells. Toxicol Mech Methods. 2006;16(4):173-80.

[2] Roslan J, et al. Quercetin ameliorates oxidative stress, inflammation and apoptosis in the heart of streptozotocin-nicotinamide-induced adult male diabetic rats. Biomed Pharmacother. 2016 Dec 24;86:570-582

[3] Fushima T, et al. Nicotinamide ameliorates a preeclampsia-like condition in mice with reduced uterine perfusion pressure. Am J Physiol Renal Physiol. 2016 Dec 7:ajprenal.00501.2016

[4] Suzuki E, et al. Protective effect of nicotinamide against poly(ADP-ribose) polymerase-1-mediated astrocyte death depends on its transporter-mediated uptake. Life Sci. 2010 Apr 24;86(17-18):676-82.

[5] Peck B, et al. SIRT inhibitors induce cell death and p53 acetylation through targeting both SIRT1 and SIRT2. Mol Cancer Ther. 2010 Apr;9(4):844-55.

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