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当前位置:首页 > 产品中心 > 免疫抑制剂 > Cyclosporine
Cyclosporine

CAS 号: 59865-13-3 (中文同义词:环孢素)

所有产品仅用于科学研究,不得用于人体或动物实验。

目录号:HD00410

分子式:C62H111N11O12

分子量:1202.61

纯度:≥95%

长期储存条件:Store in a tight container at 2-8℃,protect from light.

描述:An immunosuppressant which binds to the cyclophilin

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Cyclosporin A is an immunosuppressant drug that binds cyclophilin D, inhibiting the phosphatase activity of calcineurin in T cells (IC50 = 5 nM). Cyclosporin A is a small cyclic peptide acting as a novel antilymphocytic agent. Cyclosporin A significantly decreases CD11a/CD18 in the lungs, as well as TNFalpha and IL-1 beta levels in the fluid leakage of the pleural cavity 4 h and 48 h after pleurisy induction.

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[1] Jorgensen, K.A., Koefoed-Nielsen, P.B., and Karamperis, N. Calcineurin phosphatase activity and immunosuppression. A review on the role of calcineurin phosphatase activity and the immunosuppressive effect of cyclosporin A and tacrolimus. Scand. J. Immunol. 57(2), 93-98 (2003).

[2] Mrowietz, U. Macrolide immunosuppressants. Eur. J. Dermatol. 9(5), 346-351 (1999).

[3] Fruman, D.A., Klee, C.B., Bierer, B.E., et al. Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A. Proc. Nat. Acad. Sci. USA 89(9), 3686-3690 (1992).

[4] Dalmarco EM, et al. Cyclosporin A inhibits CD11a/CD18 adhesion molecules due to inhibition of TNFalpha and IL-1 beta levels in the mouse model of pleurisy induced by carrageenan. Cell Adh Migr. 2008 Oct-Dec;2(4):231-5.

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