CAS 号： 59865-13-3 （中文同义词：环孢素）
长期储存条件：Store in a tight container at 2-8℃,protect from light.
描述：An immunosuppressant which binds to the cyclophilin
Cyclosporin A is an immunosuppressant drug that binds cyclophilin D, inhibiting the phosphatase activity of calcineurin in T cells (IC50 = 5 nM). Cyclosporin A is a small cyclic peptide acting as a novel antilymphocytic agent. Cyclosporin A significantly decreases CD11a/CD18 in the lungs, as well as TNFalpha and IL-1 beta levels in the fluid leakage of the pleural cavity 4 h and 48 h after pleurisy induction.
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 Dalmarco EM, et al. Cyclosporin A inhibits CD11a/CD18 adhesion molecules due to inhibition of TNFalpha and IL-1 beta levels in the mouse model of pleurisy induced by carrageenan. Cell Adh Migr. 2008 Oct-Dec;2(4):231-5.