Wilforlide A is a triterpene that has been found in T. wilfordii and has anti-inflammatory and immune suppressive effects. Wilforlide A in combination with triptolide reduces inflammation, bone damage, and synovial hyperplasia in the inflamed joints in a rat model of collagen-induced arthritis.

[1] Mei Xue, et al. Comparative study on the anti-inflammatory and immune suppressive effect of Wilforlide A. Fitoterapia

[2] Zhu, X., Zhang, J., Huo, R., et al. Evaluation of the efficacy and safety of different Tripterygium preparations on collagen-induced arthritis in rats. J. Ethnopharmacol. 158(Pt A), 283-290 (2014).