CAS 号： 38748-32-2 （中文同义词：雷公藤-甲素（雷公藤多甙））
所有产品仅用于科学研究，不得用于人体或动物实验。
目录号：HD00413
分子式：C20H24O6
分子量：360.40
纯度：≥95%
长期储存条件：Store in a tight container between 2-8℃, under nitrogen.
描述：A diterpenoid triepoxide extracted from the root of Tripterygium wilfordii
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Triptolide, a natural product derived from the Chinese plant Tripterygium wilfordii, is reported to exhibit antitumor effects in a broad range of cancers. Triptolide inhibits MDM2 at the transcriptional level by suppressing its mRNA synthesis. Triptolide is a promising immunosuppressive and anti-inflammatory agent.
[1] Huang M, et al. Triptolide inhibits MDM2 and induces apoptosis in acute lymphoblastic leukemia cells through a p53-independent pathway. Mol Cancer Ther. 2013 Feb;12(2):184-94.
[2] Xu P, et al. Triptolide Inhibited Cytotoxicity of Differentiated PC12 Cells Induced by Amyloid-Beta25-35 via the Autophagy Pathway. PLoS One. 2015 Nov 10;10(11):e0142719.
[3] Kong LL, et al. Inhibition of P-glycoprotein Gene Expression and Function Enhances Triptolide-induced Hepatotoxicity in Mice. Sci Rep. 2015 Jul 2;5:11747.
[4] Zhang W, et al. Triptolide Combined with Radiotherapy for the Treatment of Nasopharyngeal Carcinoma via NF-κB-Related Mechanism. Int J Mol Sci. 2016 Dec 19;17(12). pii: E2139.
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