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Valinomycin

CAS 号: 2001-95-8 (中文同义词:缬氨霉素)

所有产品仅用于科学研究,不得用于人体或动物实验。

目录号:HD00425

分子式:C54H90N6O18

分子量:1111.32

纯度:≥95%

长期储存条件:Store in a tight container at -80℃.

描述:A cyclic depsipeptide antibiotic

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Valinomycin is a depsipeptide antibiotic which selectively translocates potassium across biologic membranes. This potassium ionophore was observed to inhibit phytohemagglutinin-stimulated blastogenesis and proliferation in human lymphocytes.

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参考文献

[1] Daniele RP, et al. A potassium ionophore (valinomycin) inhibits lymphocyte proliferation by its effects on the cell membrane. Proc Natl Acad Sci U S A. 1976 Oct;73(10):3599-602.

[2] Kondapalli C, et al. PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65. Open Biol. 2012 May;2(5):120080.

[3] Tosteson DC, et al. The effect of valinomycin on potassium and sodium permeability of HK and LK sheep red cells. J Gen Physiol. 1967 Dec;50(11):2513-25.

[4] Abdalah R, et al. Valinomycin-induced apoptosis in Chinese hamster ovary cells. Neurosci Lett. 2006 Sep 11;405(1-2):68-73.

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