CAS 号: 96829-58-2 (中文同义词:奥利司他)
所有产品仅用于科学研究,不得用于人体或动物实验。
目录号:HD00349
分子式:C29H53NO5
分子量:495.73
纯度:≥95%
长期储存条件:Store in a tight container at -20℃.
描述:Inhibitor of fatty acid synthase
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Orlistat (Tetrahydrolipstatin) is a well-known irreversible inhibitor of pancreatic and gastric lipases. Orlistat is also an inhibitor of fatty acid synthase (FASN), is used orally for long-term research of obesity. Anti-atherosclerotic effect.
[1] Zhi J, et al. Review of limited systemic absorption of orlistat, a lipase inhibitor, in healthy human volunteers. J Clin Pharmacol. 1995 Nov;35(11):1103-8.
[2] Zhang E, et al. Glycycoumarin Sensitizes Liver Cancer Cells to ABT-737 by Targeting De Novo Lipogenesis and TOPK-Survivin Axis. Nutrients. 2018 Mar 15;10(3). pii: E353.
[3] Padwal R, et al. Long-term pharmacotherapy for obesity and overweight. Cochrane Database Syst Rev. 2004;(3):CD004094.
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