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Validamycin A

CAS 号: 37248-47-8 (中文同义词:井冈霉素A)

所有产品仅用于科学研究,不得用于人体或动物实验。

目录号:HD00367

分子式:C20H35NO13

分子量:497.49

纯度:≥95%

长期储存条件:Store in a tight container between 2-8℃, protect from light, stored under nitrogen.

描述:Fungicidal, is an agricultural antibiotic.

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Validamycin A, a fungicidal, is an agricultural antibiotic. Validamycin A is originally isolated from Streptomyces hygroscopicus var. limoneus. Validamycin A inhibits the growth of A. flavus, with a MIC of 1 μg/mL. Validamycin A shows potent inhibitory activity against trehalase of Rhizoctonia solani, with an IC50 of 72 μM. Validamycin A is a reversible tyrosinase inhibitor, with a Ki of 5.893 mM.

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参考文献

[1] Napasawan Plabutong, et al. The Inhibitory Effect of Validamycin A on Aspergillus flavus. Int J Microbiol. 2020; 2020: 3972415.

[2] N Asano, et al. Effect of validamycins on glycohydrolases of Rhizoctonia solani. J Antibiot (Tokyo). 1987 Apr;40(4):526-32.

[3] Zhi-Jiang Wang, et al. The effect of validamycin A on tyrosinase: inhibition kinetics and computational simulation. Int J Biol Macromol. 2013 Apr;55:15-23.

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