CAS 号： 512-64-1 （中文同义词：醌霉素A）
所有产品仅用于科学研究，不得用于人体或动物实验。
目录号：HD00108
分子式：C51H64N12O12S2
分子量：1101.26
纯度：≥95%
长期储存条件：Store in a tight container at -20℃, stored under nitrogen.
描述：HIF-1α inhibitor
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Echinomycin is a highly potent and selective HIF-1α inhibitor (IC50 = 29.4 pM). Selectively inhibits HIF-1 binding to the VEGF promoter without affecting the binding of AP-1 or NF-κB. Inhibits colony formation of cancer stem cells (CSC) with a 100-fold selectivity over normal hematopoietic progenitor cells. Eradicates mouse lymphomas and human AML xenografts by eliminating CSCs.
[1] Kong D, et al. Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity. Cancer Res. 2005 Oct 1;65(19):9047-55.
[2] Wang Y, et al. Targeting HIF1α eliminates cancer stem cells in hematological malignancies. Cell Stem Cell. 2011 Apr 8;8(4):399-411.
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