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1-Methylpseudouridine

CAS 号: 13860-38-3 (中文同义词:1-甲基假尿苷)

所有产品仅用于科学研究,不得用于人体或动物实验。

目录号:HD00042

分子式:C10H14N2O6

分子量:258.23

纯度:≥98%

长期储存条件:Store in a tight container at 2-8℃.

描述:Modified Nucleoside

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1-Methylpseudouridine is a substitute for uridine in modified mRNA. This substitution has shown to increase transfection by reducing immunogenicity. The 1-methylpseudouridine substituted mRNA increases protein expression due to low immune. 1-Methylpseudouridine in mRNA enhances translation through eIF2α-dependent and independent mechanisms by increasing ribosome density.

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参考文献

[1] Yuri V Svitkin, et al. N1-methyl-pseudouridine in mRNA enhances translation through eIF2α-dependent and independent mechanisms by increasing ribosome density. Nucleic Acids Res. 2017 Jun 2;45(10):6023-6036.

[2] Sahin U., Kariko K., Tureci O.. mRNA-based therapeutics–developing a new class of drugs. Nat. Rev. Drug Discov. 2014; 13:759–780.

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